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Цви Фридлендер

Отделение: Пульмонология
Должность: Пульмонолог
Языки: Английский, Иврит
Принимает: только взрослых
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Профессор Цви Фридлендер.

Образование

Выпускник медицинского факультета Еврейского университета в Иерусалиме. 

Специализация

Общая терапия и пульмонология в медицинском центре Хадасса,

Профессиональная деятельность

Глава ассоциации пульмонологов Израиля  (сентябрь 2022-).

Профессор Фридландер также является всемирно известным исследователем в области изучения нейтрофилов и их роли в раке легких. Кроме того, с 2015 года он является членом международного органа, устанавливающего руководящие принципы лечения ХОБЛ.

Научные публикации

Human lung cancer neutrophils generate NETs with preserved anti-tumor cytotoxicity but impaired anti-migratory activity
From complexity to consensus: A roadmap for neutrophil classification
Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype
Dynamic Neutrophil Subsets and Function in Lung Transplant Recipients: Insights from a One-Year Longitudinal Pilot Study
Defining myeloid-derived suppressor cells
Is there a role for lung or bronchial biopsies for the diagnosis of mycobacterial pulmonary disease in patients with bronchiectasis?
Neutrophils in the tumor microenvironment - when a company becomes a crowd
Breath of Health: spectroscopy-based breath test for the detection of SARS-CoV-2
RNA Sequencing Reveals Unique Transcriptomic Signatures of the Thyroid in a Murine Lung Cancer Model Treated with PD-1 and PD-L1 Antibodies
Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes
The DNA methylome of human vascular endothelium and its use in liquid biopsies
How Accurate Is the Diagnosis of "Chronic Obstructive Pulmonary Disease" in Patients Hospitalized with an Acute Exacerbation?
Targeted nanoparticles modify neutrophil function in vivo
Recurrent haemoptysis: a rare diagnosis of kaposiform lymphangiomatosis and review of literature
Neutrophil phenotypes and functions in cancer: A consensus statement
Universal lung epithelium DNA methylation markers for detection of lung damage in liquid biopsies
The Bilateral Interplay between Cancer Immunotherapies and Neutrophils' Phenotypes and Sub-Populations
Editorial: Neutrophils in Cancer
Residual symptoms, lung function, and imaging findings in patients recovering from SARS-CoV-2 infection
The dual role of neutrophils in cancer
Accelerated low-density neutrophil transition in sickle cell anaemia may contribute to disease pathophysiology
Tumor-Derived Factors Differentially Affect the Recruitment and Plasticity of Neutrophils
Tumor-Associated Neutrophils Drive B-cell Recruitment and Their Differentiation to Plasma Cells
Therapeutic Success of Tiotropium/Olodaterol, Measured Using the Clinical COPD Questionnaire (CCQ), in Routine Clinical Practice: A Multinational Non-Interventional Study
Blocking Migration of Polymorphonuclear Myeloid-Derived Suppressor Cells Inhibits Mouse Melanoma Progression
The Effect of a Multidisciplinary Integrated Approach on Outcomes in Chronic Obstructive Pulmonary Disease
Prophylactic use of tranexamic acid for prevention of bleeding during transbronchial lung biopsies - A randomized, double-blind, placebo-controlled trial
NETosis in cancer: a critical analysis of the impact of cancer on neutrophil extracellular trap (NET) release in lung cancer patients vs. mice
Circulating neutrophil subsets in advanced lung cancer patients exhibit unique immune signature and relate to prognosis
Improvement In Self-Reported Physical Functioning With Tiotropium/Olodaterol In Central And Eastern European COPD Patients
Increased Regeneration Following Stress-Induced Lung Injury in Bleomycin-Treated Chimeric Mice with CD44 Knockout Mesenchymal Cells
Tumour-associated neutrophils in patients with cancer
Neutrophil Diversity in Health and Disease
Benralizumab for the Prevention of COPD Exacerbations
VICKZ1 enhances tumor progression and metastasis in lung adenocarcinomas in mice
Interactions among myeloid regulatory cells in cancer
Microenvironmental Cues Determine Tumor Cell Susceptibility to Neutrophil Cytotoxicity
Cancer-related circulating and tumor-associated neutrophils - subtypes, sources and function
Myeloid Regulatory Cells: New and Exciting Players in the Immunology of Lung Cancer
TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells
Inhaled therapies in patients with moderate COPD in clinical practice: current thinking
Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment
Control of immune cell entry through the tumour vasculature: a missing link in optimising melanoma immunotherapy?
Neutrophils as active regulators of the immune system in the tumor microenvironment
The association between osteopontin gene polymorphisms, osteopontin expression and sarcoidosis
Characteristics of Sarcoidosis in Patients with Previous Malignancy: Causality or Coincidence?
Organizing pneumonia following treatment with pembrolizumab for metastatic malignant melanoma - A case report
Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: A transcriptomics analysis of pro- vs. antitumor TANs
Endobrochial Ultrasound Needle Breakdown During Transbronchial Needle Aspiration
The diversity of circulating neutrophils in cancer
Plasticity beyond cancer cells and the "immunosuppressive switch"
Cluster of Fusarium solani isolations in a Bronchoscopy Unit
Recurrent Eosinophilic Pneumonia in a Patient with Isolated Immunoglobulin M Deficiency and Celiac Disease
Promoting metastasis: neutrophils and T cells join forces
Splenectomy inhibits non-small cell lung cancer growth by modulating anti-tumor adaptive and innate immune response
Isolation and Characterization of Neutrophils with Anti-Tumor Properties
Surgical cytoreduction restores the antitumor efficacy of a Listeria monocytogenes vaccine in malignant pleural mesothelioma
Overexpression of Telomerase Protects Human and Murine Lung Epithelial Cells from Fas- and Bleomycin-Induced Apoptosis via FLIP Upregulation
Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer
The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment
Neutrophils recruit regulatory T-cells into tumors via secretion of CCL17--a new mechanism of impaired antitumor immunity
Modifying tumor-associated macrophages: An important adjunct to immunotherapy
Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression
Using macrophage activation to augment immunotherapy of established tumours
Changes in the local tumor microenvironment in recurrent cancers may explain the failure of vaccines after surgery
Randomized controlled crossover trial of a new oscillatory device as add-on therapy for COPD
Cytoreduction surgery reduces systemic myeloid suppressor cell populations and restores intratumoral immunotherapy effectiveness
A positive-margin resection model recreates the postsurgical tumor microenvironment and is a reliable model for adjuvant therapy evaluation
Characterization of surgical models of postoperative tumor recurrence for preclinical adjuvant therapy assessment
Tumor-associated neutrophils: friend or foe?
Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils
Treating tumors with a vaccinia virus expressing IFNβ illustrates the complex relationships between oncolytic ability and immunogenicity
Neoadjuvant in situ gene-mediated cytotoxic immunotherapy improves postoperative outcomes in novel syngeneic esophageal carcinoma models
Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation
Sildenafil to facilitate weaning from inhaled nitric oxide and mechanical ventilation in a patient with severe secondary pulmonary hypertension and a patent foramen ovale
Pharmacologic activation of the innate immune system to prevent respiratory viral infections
Chemotherapy delivered after viral immunogene therapy augments antitumor efficacy via multiple immune-mediated mechanisms
Association between CD14 gene polymorphisms and disease phenotype in sarcoidosis
Monocyte chemoattractant protein-1 blockade inhibits lung cancer tumor growth by altering macrophage phenotype and activating CD8+ cells
Exogenous lipoid pneumonia caused by paraffin in an amateur fire breather
Activation of the nucleotide oligomerization domain signaling pathway by the non-bacterially derived xanthone drug 5'6-dimethylxanthenone-4-acetic acid (Vadimezan)
CCL2 blockade augments cancer immunotherapy
Expression of IFN-beta enhances both efficacy and safety of oncolytic vesicular stomatitis virus for therapy of mesothelioma
Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN
Evaluation of an attenuated vesicular stomatitis virus vector expressing interferon-beta for use in malignant pleural mesothelioma: heterogeneity in interferon responsiveness defines potential efficacy
The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer
Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy
Bronchoscopy in octogenarians
B-cell depletion using an anti-CD20 antibody augments antitumor immune responses and immunotherapy in nonhematopoetic murine tumor models
Association between cytomegalovirus infection and venous thromboembolism
Telomerase activity in bleomycin-induced epithelial cell apoptosis and lung fibrosis
Late-onset sarcoidosis after liver transplantation for primary biliary cirrhosis
Obstructing tracheal pulmonary Langerhans cell histiocytosis
Recurrent infusion phlebitis induced by cyclosporine
Osteomyelitis of the pubis after strenuous exercise. A case report and review of the literature
Myocardial infarction in a patient with beta-thalassemia major: first report
Metastatic carcinoma presenting with concomitant eosinophilia and thromboembolism
Pleural effusion
Resistance to adjuvant arthritis is due to protective antibodies against heat shock protein surface epitopes and the induction of IL-10 secretion
The evaluation of pleural effusions in patients with heart failure
Pneumomediastinum following drug abuse
Mefloquine-induced acute hepatitis
Monocytes confer CD14 antigenicity on activated lymphocytes
Changes in cytokine production of breast cancer patients treated with interferons
Multidrug resistance: its significance in hematological malignancies and its role in normal tissues and blood cells
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