Алекс Гилелес-Хилель

Должность: Пульмонолог, педиатр
Языки: Русский, Английский
Принимает: детей и взрослых

Доктор Алекс Гилелес-Хилель - старший детский пульмонолог и специалист по медицине сна.

Профессиональная деятельность

Клинические интересы доктора Гилелеса-Хилеля включают детские легочные заболевания, недоношенность, синдром обструктивного апноэ во время сна, кистозный фиброз и ожирение.
В лаборатории доктора Гилелеса-Хилеля ведется изучение роли обструктивного апноэ сна в развитии атеросклероза, метаболической дисфункции и рака.
Исследуется также взаимодействие между гипоксией, жировой тканью и сосудистой системой. Другое направление исследований - моделирование респираторных заболеваний, таких как астма, кистозный фиброз и первичная цилиарная дискинезия, с использованием органоидов (совместно с центром органоидов клиники Хадасса).

Научные публикации

Sustained hypoxia but not intermittent hypoxia induces HIF-1α transcriptional response in human aortic endothelial cells
Sleep-disordered breathing and diabetes mellitus: a deadly duo
Comprehensive pulmonary function analysis identifies predominant obstructive phenotype in former premature infants around one year of age
Sex bias in pain management decisions
Advances in Sleep-Disordered Breathing in Children
Things We Do for No Reason™: Routine respiratory pathogen panels for emergency department and hospitalized patients
Changes in Sleep in Children and Adults with Cystic Fibrosis and Primary Ciliary Dyskinesia over Time and after CFTR Modulator Therapy
The association of obstructive sleep apnea and behavioral insomnia in children ages 10 and under
Clinical and functional efficacy of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis carrying the N1303K mutation
Changes in ventilation modes in the last decade and their impact on the prevalence of bronchopulmonary dysplasia in preterm infants
Chronic Intermittent Hypoxia during Sleep Causes Browning of Interscapular Adipose Tissue Accompanied by Local Insulin Resistance in Mice
Sleep disorders in children with celiac disease: a prospective study
The clinical yield of bronchoscopy in the management of cystic fibrosis: A retrospective multicenter study
The utility of glucose area under the curve from the oral glucose tolerance test as a screening tool for cystic fibrosis-related diabetes
Physicians prescribe fewer analgesics during night shifts than day shifts
Respiratory physiotherapy in patients with cystic fibrosis and upper limb deep vein thrombosis
Intermittent by day, sustained by night-the worst of both hypoxias?
Modelling of primary ciliary dyskinesia using patient-derived airway organoids
Neurological and neurodevelopmental symptoms in children with familial Mediterranean fever and their siblings
Heterogeneity of Melanoma Cell Responses to Sleep Apnea-Derived Plasma Exosomes and to Intermittent Hypoxia
A wake-up call: Time to raise physicians' awareness of the consequences of fatigue
Academic activism on behalf of children during the COVID-19 pandemic in Israel; beyond public health advocacy
Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span
Sleep in children with cystic fibrosis: More under the covers
Effects of the COVID-19 lockdown on sleep duration in children and adolescents: A survey across different continents
How abnormal is the normal? Clinical characteristics of CF patients with normal FEV1
Sleep disorders in children with asthma
Sleep education improves knowledge but not sleep quality among medical students
Sickle cell disease and obstructive sleep apnea-bad news for the brain
Betamethasone versus dexamethasone for inpatient preschool wheezing-A case-control study
The effect of C-reactive protein on chest X-ray interpretation: A decision-making experiment among pediatricians
Whole-exome sequencing accuracy in the diagnosis of primary ciliary dyskinesia
APNEA OF PREMATURITY - PATHOPHYSIOLOGY, TREATMENT & PROGNOSIS
Ivacaftor in People with Cystic Fibrosis and a 3849+10kb CT or D1152H Residual Function Mutation
Escalation of sleep disturbances amid the COVID-19 pandemic: a cross-sectional international study
Acute and chronic sleep deprivation in residents: Cognition and stress biomarkers
Hijab Pin Ingestions
Understanding the pathophysiological mechanisms of cardiometabolic complications in obstructive sleep apnoea: towards personalised treatment approaches
Sleep disorders in cystic fibrosis: A systematic review and meta-analysis
Prematurity as a Risk Factor of Sleep-Disordered Breathing in Children Younger Than Two Years: A Retrospective Case-Control Study
Somatic growth in cystic fibrosis
Sleep disorders in patients with primary ciliary dyskinesia, cystic fibrosis with and without pancreatic insufficiency
Giant lung cysts following necrotizing pneumonia: Resolution with conservative treatment
Chemoreflex failure and sleep-disordered breathing in familial dysautonomia: Implications for sudden death during sleep
Pyogenic sacroiliitis in children: don't forget the very young
Exosomes and Metabolic Function in Mice Exposed to Alternating Dark-Light Cycles Mimicking Night Shift Work Schedules
Clinical impact of Pseudomonas aeruginosa colonization in patients with Primary Ciliary Dyskinesia
Activation of the Integrated Stress Response and Metabolic Dysfunction in a Murine Model of Sleep Apnea
Altered CD8+ T-Cell Lymphocyte Function and TC1 Cell Stemness Contribute to Enhanced Malignant Tumor Properties in Murine Models of Sleep Apnea
Prolonged Exposures to Intermittent Hypoxia Promote Visceral White Adipose Tissue Inflammation in a Murine Model of Severe Sleep Apnea: Effect of Normoxic Recovery
Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36
Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins
Visceral White Adipose Tissue after Chronic Intermittent and Sustained Hypoxia in Mice
Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice
Tumor Cell Malignant Properties Are Enhanced by Circulating Exosomes in Sleep Apnea
Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation
The Challenges of Precision Medicine in Obstructive Sleep Apnea
Biological plausibility linking sleep apnoea and metabolic dysfunction
Association of chronic Candida albicans respiratory infection with a more severe lung disease in patients with cystic fibrosis
Evaluation of circulating markers of hepatic apoptosis and inflammation in obese children with and without obstructive sleep apnea
Insights into Selected Aspects of Pediatric Sleep Medicine
Effects of adenotonsillectomy on plasma inflammatory biomarkers in obese children with obstructive sleep apnea: A community-based study
Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: effect of tumor microenvironment
Hemoglobinopathies and sleep--The road less traveled
Chronic sleep fragmentation induces endothelial dysfunction and structural vascular changes in mice
Early intermittent hypoxia induces proatherogenic changes in aortic wall macrophages in a murine model of obstructive sleep apnea
Inflammatory markers and obstructive sleep apnea in obese children: the NANOS study
Correlation between computed tomography expression of pulmonary hypertension and severity of lung disease in cystic fibrosis patients
Differences in the pattern of structural abnormalities on CT scan in patients with cystic fibrosis and pancreatic sufficiency or insufficiency
CT appearance of the pelvis after Cesarean delivery--what is considered normal?
Показать ещё 62 статьи Скрыть статьи
Заболевания
Гиперсомния
Муковисцидоз
Обструктивное апноэ сна
Первичная цилиарная дискинезия
Нарушения сна
Процедуры
Полисомнография
CPAP-терапия
Остались вопросы?
Напишите нам и мы свяжемся с вами в течение ближайшего времени и ответим на все интересующие вопросы