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Александр Лоссос

Профессор Александр Лоссос.

Отделение: Неврология, Онкология
Должность: Невролог, онколог
Языки: Английский, Иврит, Русский
Принимает: детей и взрослых
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Профессор Александр Лоссос.

Специализация

Специалист в области нейроонкоогии.

Профессиональная деятельность

Руководитель нейроонкологической службы.

Научные публикации

Amylopectinosis of the fatal epilepsy Lafora disease resists autophagic glycogen catabolism
Short report: Plasma based biomarkers detect radiation induced brain injury in cancer patients treated for brain metastasis: A pilot study
Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti-PD-1 Monotherapy: A Report from the International RRD Consortium
Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics
A case report of unilateral cervical lymphadenopathy and multiple cranial neuropathies following mRNA-COVID-19 vaccination
European Association of Neuro-Oncology (EANO) guidelines for treatment of primary central nervous system lymphoma (PCNSL)
A homozygous variant in CHMP3 is associated with complex hereditary spastic paraplegia
Unique Ataxia-Oculomotor Apraxia 2 (AOA2) in Israel with Novel Variants, Atypical Late Presentation, and Possible Identification of a Poison Exon
Rituximab, methotrexate, procarbazine and lomustine (R-MPL) for the treatment of primary Central nervous system lymphoma
Biallelic Variants in the Ectonucleotidase ENTPD1 Cause a Complex Neurodevelopmental Disorder with Intellectual Disability, Distinct White Matter Abnormalities, and Spastic Paraplegia
Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency
Prolonged Hiccups Following a Single Oral Dose of Prednisone
SCLC, Paraneoplastic Dermatomyositis, Positive Transcription Intermediary Factor 1-γ, and Point Mutation in the Transcription Intermediary Factor 1-γ Coding Gene: A Case Report
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism
Multi-system neurological disorder associated with a CRYAB variant
[18F]-FDHT PET/CT as a tool for imaging androgen receptor expression in high-grade glioma
Two intronic cis-acting variants in both alleles of the POLR3A gene cause progressive spastic ataxia with hypodontia
VHL-Related Neuroendocrine Neoplasms And Beyond: An Israeli Specialized Center Real-Life Report
DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells
Neurological misdiagnoses of lymphoma
Germline-driven replication repair-deficient high-grade gliomas exhibit unique hypomethylation patterns
Intrathecal cytosine arabinoside-induced progression of chronic methotrexate myelopathy
MYORG Mutations: a Major Cause of Recessive Primary Familial Brain Calcification
MYORG is associated with recessive primary familial brain calcification
Early hydrocephalus in Listeria meningitis: Case report and review of the literature
Guaiacol as a drug candidate for treating adult polyglucosan body disease
Androgen receptor: a potential therapeutic target for glioblastoma
Neurological variability in chemotherapy-induced posterior reversible encephalopathy syndrome associated with thrombotic microangiopathy: Case reports and literature review
Neurologic complications of immune checkpoint inhibitors
Preliminary results of immune modulating antibody MDV9300 (pidilizumab) treatment in children with diffuse intrinsic pontine glioma
A novel image-based high-throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease
Defective ATP breakdown activity related to an ENTPD1 gene mutation demonstrated using 31P NMR spectroscopy
Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy
Treatment inferred from mutations identified using massive parallel sequencing leads to clinical benefit in some heavily pretreated cancer patients
Clinical utility and treatment outcome of comprehensive genomic profiling in high grade glioma patients
Pembrolizumab: first experience with recurrent primary central nervous system (CNS) tumors
Constitutional Mismatch Repair Deficiency in Israel: High Proportion of Founder Mutations in MMR Genes and Consanguinity
Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design
Frequent misdiagnosis of adult polyglucosan body disease
Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder
Teaching NeuroImages: hypertrophic olivary degeneration in a young man with POLG gene mutation
Deep intronic GBE1 mutation in manifesting heterozygous patients with adult polyglucosan body disease
Fe/S protein assembly gene IBA57 mutation causes hereditary spastic paraplegia
Tumefactive demyelination following in vitro fertilization (IVF)
Severe methylenetetrahydrofolate reductase deficiency: clinical clues to a potentially treatable cause of adult-onset hereditary spastic paraplegia
Rosai-Dorfman disease of the central nervous system: report of 6 cases and review of the literature
A novel SCARB2 mutation in progressive myoclonus epilepsy indicated by reduced β-glucocerebrosidase activity
Delineation of C12orf65-related phenotypes: a genotype-phenotype relationship
Recessive myosin myopathy with external ophthalmoplegia associated with MYH2 mutations
Lipoid proteinosis with bilateral amygdalae calcifications, headache, and cognitive impairments
Polyglucosan neurotoxicity caused by glycogen branching enzyme deficiency can be reversed by inhibition of glycogen synthase
Aggressive leptomeningeal gliomatosis in neurofibromatosis type 1
Novel use of stenting for temporary endovascular bypass and thrombectomy in major ischemic stroke
Intradural lumbar varix resembling a tumor: case report of a magnetic resonance imaging-based diagnosis
A 63-year-old woman with urinary incontinence and progressive gait disorder
Leukoencephalopathy with neuroaxonal spheroids presenting as frontotemporal dementia
Brain metastases: a rare initial presentation of prostate cancer
Hereditary spastic paraplegia with thin corpus callosum: reduction of the SPG11 interval and evidence for further genetic heterogeneity
CSF analysis of IgH gene rearrangement in CNS lymphoma: relationship to the disease course
Phenotypic variability among adult siblings with Sjögren-Larsson syndrome
Extrathymic malignancies in patients with myasthenia gravis
Early clinical heterogeneity in choreoacanthocytosis
Extended phenotype in the transthyretin Tyr77 familial amyloid polyneuropathy
Central nervous system involvement in indolent lymphomas
A novel autosomal recessive myopathy with external ophthalmoplegia linked to chromosome 17p13.1-p12
Spinal epidural lipomatosis following haploidentical allogeneic bone marrow transplantation for non-Hodgkin lymphoma
Late-delayed cerebral involvement in systemic non-Hodgkin lymphoma: a second primary tumor or a tardy recurrence?
Frontotemporal dementia and parkinsonism with the P301S tau gene mutation in a Jewish family
Central nervous system relapse of systemic non-Hodgkin's lymphoma: results of treatment based on high-dose methotrexate combination chemotherapy
Neurotoxicity with leukoencephalopathy after a single intravenous high dose of methotrexate in a patient with lymphoma
Clinical-biochemical correlation in molecularly characterized patients with Niemann-Pick type C
Pharmacokinetics of methotrexate in cerebrospinal fluid and serum after osmotic blood-brain barrier disruption in patients with brain lymphoma
In vivo assessment of the window of barrier opening after osmotic blood-brain barrier disruption in humans
Cerebrospinal fluid lactate dehydrogenase isoenzyme analysis for the diagnosis of central nervous system involvement in hematooncologic patients
Interferon in the treatment of base of the skull hemangioendothelioma
Sudden hearing loss following acute hepatitis
Adult polyglucosan body disease in Ashkenazi Jewish patients carrying the Tyr329Ser mutation in the glycogen-branching enzyme gene
Intravascular lymphomatosis--an indolent or aggressive entity?
Leptomeningeal metastases from solid tumors: a comparison of two prospective series treated with and without intra-cerebrospinal fluid chemotherapy
Cisplatin-induced non-convulsive encephalopathy
Adult-onset Niemann-Pick type C disease. Clinical, biochemical, and genetic study
Intrafamilial heterogeneity of movement disorders: report of three cases in one family
Vincristine-induced paralytic ileus in Parkinson's disease
Intrathecal prophylaxis following autologous bone marrow transplantation for non-Hodgkin's lymphoma
Permanent neurologic deficit after inferior alveolar nerve block: a case report
Electric shock-like sensations in 42 cancer patients: clinical characteristics and distinct etiologies
Germinoma and choroid plexus papilloma coexisting in the fourth ventricle
Inclusion body myositis: atypical clinical presentations
Neurologic aspects of inflammatory bowel disease
Hereditary leukoencephalopathy and palmoplantar keratoderma: a new disorder with increased skin collagen content
Familial Sneddon's syndrome
Leptomeningeal metastases: analysis of 31 patients with sustained off-therapy response following combined-modality therapy
Intracranial haematomas following bone marrow transplantation
Optic neuritis associated with familial Mediterranean fever
GBE1 Adult Polyglucosan Body Disease
Numb chin syndrome in cancer patients: etiology, response to treatment, and prognostic significance
Spinal subarachnoid hemorrhage associated with leptomeningeal metastases
Hereditary branching enzyme dysfunction in adult polyglucosan body disease: a possible metabolic cause in two patients
Peripheral neuropathy and folate deficiency as the first sign of Crohn's disease
Orthostatic hypotension induced by vitamin B12 deficiency
Complete unilateral ophthalmoplegia as the presenting manifestation of Waldenström's macroglobulinemia
Brain SPECT imaging with Tc-99m HM-PAO in Creutzfeld-Jakob disease
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